Author/Authors :
Masao Yoshida، نويسنده , , Jun-ichiro Hayakawa، نويسنده , , Noriyuki Hayashi، نويسنده , , Toshinori Agatsuma، نويسنده , , Youko Oda، نويسنده , , Fumie Tanzawa، نويسنده , , Shiho Iwasaki، نويسنده , , Kumiko Koyama، نويسنده , , Hidehiko Furukawa، نويسنده , , Shinichi Kurakata، نويسنده , , Yuichi Sugano، نويسنده ,
Abstract :
Based on 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid[2-(cyclohexanecarbonylamino)benzothiazol-6-yl]amide (1), which shows selective cytotoxicity against tumorigenic cell lines, 2,6-dichloro-N-[2-(cyclopropanecarbonylamino)benzothiazol-6-yl]benzamide (13b) was designed and synthesized as a biologically stable derivative containing no nitro group. The highly potent derivative 13b exhibited excellent in vivo inhibitory effect on tumor growth.
