Title of article :
6-Aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles as PPAR-γ activators
Author/Authors :
Ashoke Sharon، نويسنده , , Ramendra Pratap، نويسنده , , Rit Vatsyayan، نويسنده , , Prakas R. Maulik، نويسنده , , Uma Roy، نويسنده , , Atul Goel، نويسنده , , Vishnu Ji Ram، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Various 6-aryl-3-cyano/methoxycarbonyl-4-methylsulfanyl-2H-pyran-2-ones have been synthesized as a potential substitute of 2,4-thiazolidinedione head group to express potent PPAR-γ transactivation response. Some of the screened compounds have shown promising PPAR-γ agonistic activity.
Keywords :
diabetes , PPAR , pyran-2-one , transactivation
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
