An improved synthesis of 5′-fluoro-5′-deoxyadenosines

Synthesis of 5′-fluoro-5′-deoxyadenosine (5′-FDA) and structurally similar compounds is generally a poor yielding process. This is attributed to the instability of the selected synthetic intermediates. Herein, we report a general synthesis of 5′-fluoro-5′-deoxy-N6-substituted adenosines including a high yielding access to 5′-FDA.