Title of article :
Structure–activity relationship of a series of cyclohexylpiperidines bearing an amide side chain as antagonists of the human melanocortin-4 receptor
Author/Authors :
Joseph A. Tran، نويسنده , , Joseph Pontillo، نويسنده , , Melissa Arellano، نويسنده , , Beth A. Fleck، نويسنده , , Fabio C. Tucci، نويسنده , , Dragan Marinkovic، نويسنده , , Caroline W. Chen، نويسنده , , John Saunders، نويسنده , , Alan C. Foster، نويسنده , , Chen Chen، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Pages :
5
From page :
3434
To page :
3438
Abstract :
A series of cyclohexylpiperazines was synthesized as potent and selective antagonists of the human MC4 receptor. Compound 14t displayed binding affinity (Ki) of 4.2 and 1100 nM at MC4R and MC3R, respectively.
Keywords :
Melanocortin-4 receptor , Cyclohexylpiperazine , Antagonist
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2005
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
795806
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=795806
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