Title of article
Pyrrolo[1,2-a][1,4]benzodiazepine: A novel class of non-azole anti-dermatophyte anti-fungal agents
Author/Authors
Lieven Meerpoel، نويسنده , , Jef Van Gestel، نويسنده , , Frans Van Gerven، نويسنده , , Filip Woestenborghs، نويسنده , , Patrick Marichal، نويسنده , , Vic Sipido، نويسنده , , Gilkerson Terence، نويسنده , , Roger Nash، نويسنده , , David Corens، نويسنده , , Ray D. Richards، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
3453
To page
3458
Abstract
Broad screening revealed compound 1a to be a novel anti-fungal agent with high specificity towards dermatophytes. The anti-fungal structure–activity relationship of this novel class of 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepines is described together with its mode of action that appeared to be the inhibition of squalene epoxidase. Preliminary in vivo results of the most active compounds are also reported.
Keywords
4]benzodiazepine , Anti-dermatophyte , Anti-fungal
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795810
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