Title of article
Investigation of glycine α-ketoamide HCV NS3 protease inhibitors: Effect of carboxylic acid isosteres
Author/Authors
Wei Han، نويسنده , , Xiangjun Jiang، نويسنده , , Zilun Hu، نويسنده , , Zelda R. Wasserman، نويسنده , , Carl P. Decicco، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
3487
To page
3490
Abstract
The design and synthesis of tetrapeptide-based α-ketoamides containing prime side acid isosteres HCV NS3 protease inhibitors are described. Tetrazole, sulfonic acid, and N-sulfonylcarboxamids were demonstrated to be efficient carboxylic acid replacements. Further optimization yielded a series of potent HCV NS3 protease inhibitors with IC50 of 0.020–0.060 μM.
Keywords
HCV protease inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795816
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