Title of article :
Novel antiglaucoma prodrugs and codrugs of ethacrynic acid
Author/Authors :
Grazyna Cynkowska، نويسنده , , Tadeusz Cynkowski، نويسنده , , Abeer A. Al-Ghananeem، نويسنده , , Hong Guo، نويسنده , , Paul Ashton، نويسنده , , Peter A. Crooks، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
The purpose of this study was to synthesize a novel prodrug of ethacrynic acid (ECA) with short chain polyethylene glycols (PEGs) and codrugs of ECA with the β-adrenergic blocking agent atenolol (ATL) or timolol (TML) to overcome the adverse effects of ECA and to enhance its physicochemical properties.
Keywords :
Ethacrynic acid , Timolol , atenolol , prodrug , Codrug , Glaucoma
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
