Title of article
Inhibition of tumor cell proliferation by thieno[2,3-d]pyrimidin-4(1H)-one-based analogs
Author/Authors
Yanong D. Wang، نويسنده , , W. Steven Johnson، نويسنده , , Dennis Powell، نويسنده , , John P. McGinnis، نويسنده , , Miriam Miranda، نويسنده , , Sridhar K. Rabindran، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
3763
To page
3766
Abstract
On the basis of a screening lead from an assay using a pair of p21 isogenic cell lines (p21-proficient cells and p21-deficient cells) to identify chemoselective agents, a series of novel thieno[2,3-d]pyrimidin-4(1H)-one-based analogs was prepared. Some analogs inhibited the growth of human colon tumor cells.
Keywords
p21 isogenic cell lines , 3-d]pyrimidin-4(1H)-ones , Anti-Proliferative
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795875
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