Title of article
Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors
Author/Authors
Rong Sheng، نويسنده , , Xiao Lin، نويسنده , , Jingya Li، نويسنده , , Yanke Jiang، نويسنده , , Zhicai Shang، نويسنده , , Yongzhou Hu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
3834
To page
3837
Abstract
A series of 2-phenoxy-indan-1-one derivatives have been designed, synthesized, and tested as acetylcholinesterase inhibitors. The most potent compound exhibited high AChE inhibitory activity (IC50 = 50 nM), and the molecular docking study indicated that it was nicely accommodated by AChE.
Keywords
Acetylcholinesterase inhibitors , 2-Phenoxy-indan-1-one derivatives , synthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795889
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