Title of article
Comparison of different heterocyclic scaffolds as substrate analog PDE5 inhibitors
Author/Authors
Helmut Haning، نويسنده , , Ulrich Niew?hner، نويسنده , , Thomas Schenke، نويسنده , , Thomas Lampe، نويسنده , , Alexander Hillisch، نويسنده , , Erwin Bischoff، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
8
From page
3900
To page
3907
Abstract
Several different heterocyclic systems were compared as PDE5 inhibitor scaffolds. In addition to the known 3H-imidazo[5,1-f][1,2,4]triazin-4-ones and pyrazolopyrimidinones, isomeric imidazo[1,5-a][1,3,5]triazin-4(3H)-ones were also shown to be potent and selective PDE inhibitor scaffolds with in vivo activity. SAR trends were elucidated for sulfonamide derivatives with generality across different scaffolds.
Keywords
Heterocycles , PDE5 inhibition
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795903
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