Title of article
Synthesis and assay of isoquinoline derivatives as HIV-1 Tat–TAR interaction inhibitors
Author/Authors
Meizi Jiang، نويسنده , , Dekai Yuan، نويسنده , , Wei Lin، نويسنده , , Ruifang Pang، نويسنده , , Xiaolin Yu، نويسنده , , Ming Yang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
3978
To page
3981
Abstract
Four new isoquinoline derivatives bearing guanidinium group or amino group-terminated side chain were synthesized to target the HIV-1 TAR element. Their abilities to bind TAR RNA and inhibit Tat–TAR RNA interaction were determined by CE analysis, a Tat-dependent HIV-1 LTR-driven CAT assay and SIV-induced syncytium evaluation.
Keywords
isoquinoline , Ce , Tat–TAR interaction
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795918
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