Title of article :
A prodrug system for hydroxylamines based on esterase catalysis
Author/Authors :
Ana Conejo-Garcia، نويسنده , , Andrea G. Prescott and Christopher J. Schofield، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
The synthesis and reactivity of hydroxy hydroxamates as models for a prodrug form of hydroxylamine are described. γ-Hydroxy hydroxamates were found to enable hydroxylamine release via lactonisation. Hydroxamates were found to undergo esterase catalysed hydrolysis.
Keywords :
Prodrug , Lactonisation , esterase , Hydroxylamine , hydroxamates , Intramolecular cyclisation
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
