Author/Authors :
David F. Corbett، نويسنده , , Tom D. Heightman، نويسنده , , Stephen F. Moss، نويسنده , , Steven M. Bromidge، نويسنده , , Sara A. Coggon، نويسنده , , Mark J. Longley، نويسنده , , Ana Maria Roa، نويسنده , , Jennifer A. Williams، نويسنده , , David R. Thomas، نويسنده ,
Abstract :
High-throughput screening of an array of biphenylmethylamines synthesised by high-throughput solid-phase chemistry resulted in the identification of compounds with high-affinity for the 5-ht5A receptor. The structure–activity relationship within this series and further array synthesis led to the identification of the biphenylmethylamine derivative 11, a potent and selective 5-ht5A receptor antagonist.
Keywords :
5-ht5A Receptor , 5-ht5A Antagonist , High-throughput chemistry , solid-phase synthesis
