Title of article :
Synthesis and structure–activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists
Author/Authors :
Xiaojun Han ، نويسنده , , Sokhom S. Pin، نويسنده , , Kevin Burris، نويسنده , , Lawrence K. Fung، نويسنده , , Stella Huang، نويسنده , , Matthew T. Taber، نويسنده , , Jie Zhang، نويسنده , , Gene M. Dubowchik، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
8-Aryl-1,3a,8-triaza-cyclopenta[a]indenes represent a novel series of high binding affinity corticotropin-releasing factor 1 receptor antagonists. Here, we report their synthesis, SAR, and pharmacokinetic properties of compound 8e (Ki = 23 nM).
Keywords :
Corticotropin-releasing factor 1 , Antagonists , SAR , Pharmacokinetic properties
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
