Title of article :
Discovery of halogenated eurypamide B analogues as inhibitors of lipid droplet accumulation in macrophages
Author/Authors :
Rika Obata، نويسنده , , Taichi Ohshiro، نويسنده , , Hiroshi Tomoda، نويسنده , , Shigeru Nishiyama، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Halogenated cyclic isodityrosine–tripeptides were synthesized as analogues of a marine natural product, eurypamide B. Although the original eurypamides showed no inhibitory activity, the new analogues were found to inhibit lipid droplet accumulation in macrophages with a low micromolar IC50 value.
Keywords :
Thallium(III) oxidation , Lipid droplet accumulation inhibitor , Eurypamide , Antiatherosclerotic agents , Cyclic isodityrosine
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
