Title of article
5-Substituted 4-anilinoquinazolines as potent, selective and orally active inhibitors of erbB2 receptor tyrosine kinase
Author/Authors
Peter Ballard، نويسنده , , Robert H. Bradbury، نويسنده , , Laurent F.A. Hennequin، نويسنده , , D. Mark Hickinson، نويسنده , , Paul D. Johnson، نويسنده , , Jason G. Kettle، نويسنده , , Teresa Klinowska، نويسنده , , Remy Morgentin، نويسنده , , Donald J. Ogilvie، نويسنده , , Annie Olivier، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4226
To page
4229
Abstract
Starting from a 6,7-substituted quinazoline lead 4, optimisation of 5-substituted quinazolines containing an extended aniline motif led to potent and selective inhibitors of erbB2 receptor tyrosine kinase, and a representative compound 12a inhibited tumour growth in a mouse xenograft model.
Keywords
ErbB2 , Anilinoquinazoline , Receptor tyrosine kinase
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795963
Link To Document