Title of article :
2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists
Author/Authors :
Cecilia Mattsson Petersen، نويسنده , , Clas Sonesson، نويسنده , , Anna Sandahl، نويسنده , , Hartmut E. Greiner، نويسنده , , Michael Gassen، نويسنده , , J?rg Plaschke، نويسنده , , Joachim Leibrock، نويسنده , , Henning B?ttcher، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A series of 2-alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles were synthesized and evaluated for their 5-HT6 activity. The most potent agonist in this series was 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole with an IC50 = 7.4 nM in 3H-LSD binding and an EC50 = 1.0 nM in a functional assay measuring production of cyclic AMP.
Keywords :
6-Tetrahydropyridin-4-yl)-1H-indole , 5-HT6 , 5-Hydroxytryptamine6 agonist , 3-(1 , 2 , 3
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
