Author/Authors :
Shinnosuke Hosoda، نويسنده , , Aya Tanatani، نويسنده , , Ken-ichi Wakabayashi، نويسنده , , Yusuke Nakano، نويسنده , , Hiroyuki Miyachi، نويسنده , , Kazuo Nagasawa، نويسنده , , Yuichi Hashimoto، نويسنده ,
Abstract :
Ligands possessing dual vitamin D3-agonistic (estimated as HL-60 monocytic cell differentiation induction) and androgen-antagonistic (estimated as testosterone-induced SC-3 cell growth inhibition) activities with various activity spectra were prepared based on a substituted bis-phenylmethane skeleton. Some of them were revealed to be potent androgen antagonists with a nonsecosteroidal vitamin D3 skeleton.
