Title of article
Privileged structure-based ligands for melanocortin receptors—tetrahydroquinolines, indoles, and aminotetralines
Author/Authors
Matthew J. Fisher، نويسنده , , Ryan T. Backer، نويسنده , , Saba Husain، نويسنده , , Hansen M. Hsiung، نويسنده , , Jeffrey T. Mullaney، نويسنده , , Thomas P. O’Brian، نويسنده , , Paul L. Ornstein، نويسنده , , Roger R. Rothhaar، نويسنده , , John M. Zgombick، نويسنده , , Karin Briner، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4459
To page
4462
Abstract
Substitution of the aryl sulfonamide moiety contained in MC4 agonist 1 with bicyclic heterocycles and aminotetralines produced compounds with MC4 activity. The heterocycles represent alternative privileged structures to that contained in 1. Compounds in which the polar group of the privileged structure was displayed in an endocyclic fashion were not as active as the parent agonist 1, while those with an exocyclic polar group afforded activity competitive with 1.
Keywords
Melanocortin receptors , Privileged structures
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796010
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