Title of article
Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease
Author/Authors
Kevin X. Chen، نويسنده , , F. George Njoroge، نويسنده , , Andrew Prongay، نويسنده , , John Pichardo، نويسنده , , Vincent Madison، نويسنده , , Viyyoor Girijavallabhan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4475
To page
4478
Abstract
The 17-membered phenylalanine-based macrocycle 6 was prepared starting from 3-iodo-phenylalanine. Macrocyclization of alkene phenyl iodide 5 was effected through a palladium-catalyzed Heck reaction. The macrocyclic α-ketoamides were active inhibitors of the HCV NS3 protease, with the C-terminal acids and amides being more potent than tert-butyl esters.
Keywords
hepatitis C virus , macrocycle , inhibitor , protease
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796014
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