Title of article
A new class of high affinity thyromimetics containing a phenyl-naphthylene core
Author/Authors
Jon J. Hangeland، نويسنده , , Todd J. Friends، نويسنده , , Arthur M. Doweyko، نويسنده , , Karin Mellstr?m، نويسنده , , Johnny Sandberg، نويسنده , , Marlena Grynfarb، نويسنده , , Denis E. Ryono، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
4579
To page
4584
Abstract
High affinity thyromimetics containing a novel phenyl-naphthylene core are reported. The functionalized core is readily accessible via a Suzuki coupling protocol. Examples of this new class of TR ligands have sub-nanomolar binding affinities for the TRβ receptor and low to modest selectivity for TRβ. They also exhibit an SAR that diverges from other thyromimetics that are based on the diaryl ether core found in 3,5,3′-triiodothyronine.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796037
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