Title of article
Minor structural modifications convert a selective PPARα agonist into a potent, highly selective PPARδ agonist
Author/Authors
Stefan Weigand، نويسنده , , Hilmar Bischoff، نويسنده , , Elke Dittrich-Wengenroth، نويسنده , , Heike Heckroth، نويسنده , , Dieter Lang، نويسنده , , Andrea Vaupel، نويسنده , , Michael Woltering، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
4619
To page
4623
Abstract
We report the solid-phase synthesis and pharmacological evaluation of a new series of small-molecule agonists of the human peroxisome proliferator-activated receptor δ (PPARδ) based on a lead structure from our PPARα program. Compound 33 showed good pharmacokinetics.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796045
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