Author/Authors :
Fedele Manna، نويسنده , , Franco Chimenti، نويسنده , , Rossella Fioravanti، نويسنده , , Adriana Bolasco، نويسنده , , Daniela Secci، نويسنده , , Paola Chimenti، نويسنده , , Cristiano Ferlini، نويسنده , , Giovanni Scambia، نويسنده ,
Abstract :
A series of substituted pyrazolines were synthesized and evaluated for their anticancer activity and for their ability to inhibit P-glycoprotein-mediated multidrug resistance by direct binding to a purified protein domain containing an ATP-binding site and a modulator interacting region. Compounds 2a and e have been found to bind to P-glycoprotein with greater affinity.
