Title of article
Identification of a potent and selective 5-HT1B receptor antagonist
Author/Authors
Paul A. Wyman، نويسنده , , Howard R. Marshall، نويسنده , , Sean T. Flynn، نويسنده , , Ron J. King، نويسنده , , Mervyn Thompson، نويسنده , , Paul W. Smith، نويسنده , , Michael S. Hadley، نويسنده , , Gary W. Price، نويسنده , , Claire M. Scott، نويسنده , , Lee A. Dawson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
4708
To page
4712
Abstract
An SAR study around the mixed 5-HT1ABD receptor antagonist SB-272183 found that introduction of cis-2,6-dimethyl substitution onto the piperazine ring was a key structural change, which imparted a combination of both excellent selectivity over the 5-HT1A and 5-HT1D receptors and low intrinsic activity. This led to the identification of the selective 5-HT1B receptor antagonist SB-616234.
Keywords
SB-616234 , 5-HT1B receptor antagonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796060
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