Author/Authors :
S. Richard Baker، نويسنده , , John Boot، نويسنده , , Michael Brunavs، نويسنده , , David Dobson، نويسنده , , Rachel Green، نويسنده , , Lorna Hayhurst، نويسنده , , Martine Keenan، نويسنده , , Louise Wallace، نويسنده ,
Abstract :
Potent and selective ligands of the α7 nicotinic acetylcholine receptor are required to understand the pharmacological effect of α7 activation. A common cross-reactivity occurs with serotonergic 5-HT3 receptors with which α7 receptors have a high sequence homology. We demonstrate that certain quinuclidine 3-biaryl carboxamides are high affinity α7 ligands with an excellent binding selectivity over 5-HT3 receptors.
