Title of article :
New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors
Author/Authors :
Bernard Hulin، نويسنده , , Shawn Cabral، نويسنده , , Michael G. Lopaze، نويسنده , , Maria A. Van Volkenburg، نويسنده , , Kim M. Andrews، نويسنده , , Janice C. Parker، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Cyclohexylglycine amides of various fluorinated pyrrolidines and azetidines were prepared and tested for activity against dipeptidyl peptidase IV and in vivo in the KK mouse model of type 2 diabetes. The tetrafluoropyrrolidide, cis-3,4-difluoropyrrolidide and the fluorinated azetidides displayed unexpectedly strong activity.
Keywords :
Dipeptidyl peptidase IV , Cyclohexylglycine , Difluoropyrrolidine , Tetrafluoropyrrolidine , Fluoroazetidine , Difluoroazetidine , DPP-IV
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
