Title of article :
Synthesis of potent and selective serotonin 5-HT1B receptor ligands
Author/Authors :
Yiyun Huang، نويسنده , , Sung-A Bae، نويسنده , , Bryan L. Roth، نويسنده , , Marc Laruelle، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A series of serotonin 5-HT1B ligands were synthesized and evaluated for their potency and selectivity against other 5-HT receptor subtypes. Many of these new compounds displayed high affinity and selectivity for the 5-HT1B receptor and compound 6c was found to have the in vitro binding profile necessary for development as a PET radioligand.
Keywords :
ligand , Serotonin 5-HT1B receptor , Synthesis
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
