Author/Authors :
Jeffry B. Franciskovich، نويسنده , , John J. Masters، نويسنده , , Jennifer M. Tinsley، نويسنده , , Trelia J. Craft، نويسنده , , Larry L. Froelich، نويسنده , , Donetta S. Gifford-Moore، نويسنده , , Valentine J. Klimkowski، نويسنده , , Jeffrey K. Smallwood، نويسنده , , Gerald F. Smith، نويسنده , , Tommy Smith، نويسنده , , Richard R. Towner، نويسنده , , Leonard C. Weir، نويسنده , , Michael R. Wiley، نويسنده ,
Abstract :
Several non-amidino S1 derivatives of the 1,2-diaminobenzene-based scaffold (4) were synthesized and evaluated for their ability to bind to the active site and inhibit the human protease factor Xa. A subset of these compounds were also evaluated for their anticoagulant effects in human plasma as measured by prothrombin time (PT).
Keywords :
1 , 2-Diaminobenzene , coagulation , Factor Xa , thrombosis
