Title of article
A new antitumor compound from the plant Oryctanthus sp. as a VEGF receptor binding inhibitor
Author/Authors
Vinod R. Hegde، نويسنده , , Haiyan Pu، نويسنده , , Mahesh Patel، نويسنده , , Adrian Jachens، نويسنده , , Vincent P. Gullo، نويسنده , , Tze-Ming Chan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
4907
To page
4909
Abstract
The 70% aqueous methanolic extract of the Peruvian plant Oryctanthus sp. was found to contain a novel saccharide of a diene α,ω-diacid. Compound 1 was identified as an inhibitor of the VEGF receptor. The structure of this compound was established based on NMR studies. Compound 1 inhibited ligand binding to the VEGF receptor with an IC50 of 5.0 μM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796098
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