Title of article
The synthesis and biological evaluation of dopamine transporter inhibiting activity of substituted diphenylmethoxypiperidines
Author/Authors
Gennady B. Lapa، نويسنده , , Gary D. Byrd، نويسنده , , Alla A. Lapa، نويسنده , , Evgeny A. Budygin، نويسنده , , Steven R. Childers، نويسنده , , Sara R. Jones، نويسنده , , Jill J. Harp، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4915
To page
4918
Abstract
The synthesis of potent 4-aryl methoxypiperidinol inhibitors of the dopamine transporter is described. Symmetrical para substituents of the benzene rings are important for high potency in binding to the dopamine transporter. 4-[Bis(4-fluorophenyl) methoxy]-1-methylpiperidine has an IC50 of 22.1 ± 5.73 nM and increases locomotor activity in mice.
Keywords
Dopamine transporter , inhibitor , Piperidinol-4 , locomotor activity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796100
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