Title of article
Design, synthesis, and bioavailability evaluation of coumarin-based prodrug of meptazinol
Author/Authors
Qiong Xie، نويسنده , , Xiaolin Wang ، نويسنده , , Xinghai Wang، نويسنده , , Zhiqiang Jiang، نويسنده , , Zhuibai Qiu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4953
To page
4956
Abstract
Based on the known coumarin-based prodrug system, a new meptazinol (Z)-3-[2-(propionyloxy) phenyl]-2-propenoic ester (3) was designed and synthesized as prodrug to minimize the first-pass effect of meptazinol (1) and improve the oral bioavailability. The prodrug (3) showed a 4-fold increase in oral bioavailability over the parent drug meptazinol in rats.
Keywords
Meptazinol , synthesis , bioavailability , Coumarin-based prodrug
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796108
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