Title of article :
A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists
Author/Authors :
Caroline J. Goodacre، نويسنده , , Steven M. Bromidge، نويسنده , , David Clapham، نويسنده , , Frank D. King، نويسنده , , Peter J. Lovell، نويسنده , , Mike Allen، نويسنده , , Lorraine P. Campbell، نويسنده , , Vicky Holland، نويسنده , , Graham J. Riley، نويسنده , , Kathryn R. Starr، نويسنده , , Brenda K. Trail، نويسنده , , Martyn D. Wood، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Pages :
5
From page :
4989
To page :
4993
Abstract :
Bisaryl cyclic ureas have been identified as high affinity 5-HT2C receptor antagonists with selectivity over 5-HT2A and 5-HT2B. Compounds such as 8 and 22 have shown oral activity in a centrally mediated pharmacodynamic model of 5-HT2C function in rodents.
Keywords :
5-HT2C receptor antagonists
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2005
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
796115
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=796115
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