Title of article
Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARγ partial agonists
Author/Authors
James F. Dropinski، نويسنده , , Taro Akiyama، نويسنده , , Monica Einstein، نويسنده , , Bahanu Habulihaz، نويسنده , , Tom Doebber، نويسنده , , Joel P. Berger، نويسنده , , Peter T. Meinke، نويسنده , , Guo Q. Shi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
5035
To page
5038
Abstract
A series of novel aryl indole-2-carboxylic acids has been identified as potent selective PPARγ modulators. Their chemical synthesis and in vitro activities are discussed. Compound 5 was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796125
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