Title of article :
Design, synthesis, and antiproliferative activity of some novel aminosubstituted xanthenones, able to overcome multidrug resistance toward MES-SA/Dx5 cells
Author/Authors :
Ioannis K. Kostakis، نويسنده , , Roxane Tenta، نويسنده , , Nicole Pouli، نويسنده , , Panagiotis Marakos، نويسنده , , Alexios-Leandros Skaltsounis، نويسنده , , Harris Pratsinis، نويسنده , , Dimitris Kletsas، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A series of novel xanthenone aminoderivatives and their pyrazole-fused counterparts possessing structural analogy to the potent anticancer agent 9-methoxypyrazoloacridine (PZA) reported. These compounds exhibited an interesting cytotoxic activity against a panel of cell lines. Most noticeably, they retain activity against the multidrug resistant MES-SA/Dx5 subline, showing resistant factors close to 1.
Keywords :
Aminoxanthenones , 3 , 2-cd]indazoles , cytotoxic activity , Cell-cycle selectivity , multidrug resistance
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
