Title of article :
Phosphinate, sulfonate, and sulfonamidate dipeptides as potential inhibitors of Escherichia coli aminopeptidase N
Author/Authors :
Ke-Wu Yang، نويسنده , , Frank C. Golich، نويسنده , , Tara K. Sigdel، نويسنده , , Michael W. Crowder، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
In an effort to prepare novel inhibitors of bacterial aminopeptidase N (PepN), the phosphinate, propenylphosphinate, decylphosphinate, sulfonate, and sulfonamidate analogs of Ala–Ala were synthesized and tested as inhibitors. Phosphinate 1 was shown to inhibit PepN with a Ki of 10 μM, and propenylphosphinate 2 and decylphosphinate 3 inhibited PepN with a Ki of ca. 1 μM. Sulfonate and sulfonamidate analogs did not inhibit PepN.
Keywords :
aminopeptidase N , Phosphinate , inhibitor
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters