Title of article
Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390
Author/Authors
Luciano Barboni، نويسنده , , Roberto Ballini، نويسنده , , Guido Giarlo، نويسنده , , Giovanni Appendino، نويسنده , , Gabriele Fontana، نويسنده , , Ezio Bombardelli، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
5182
To page
5186
Abstract
Starting from 10-deacetylbaccatin III (7), the 2-debenzoyl-2-m-methoxybenzoyl analogs of the newer generation taxoids IDN5109 (3) and IDN5390 (4) were synthesized. The biological evaluation of these compounds (5 and 6, respectively) showed a general increase of cytotoxicity, as observed in first-generation anticancer taxanes.
Keywords
Methoxylated , Newer generation taxoids , Paclitaxel , IDN5109 , IDN5390
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796152
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