Title of article :
Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390
Author/Authors :
Luciano Barboni، نويسنده , , Roberto Ballini، نويسنده , , Guido Giarlo، نويسنده , , Giovanni Appendino، نويسنده , , Gabriele Fontana، نويسنده , , Ezio Bombardelli، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Starting from 10-deacetylbaccatin III (7), the 2-debenzoyl-2-m-methoxybenzoyl analogs of the newer generation taxoids IDN5109 (3) and IDN5390 (4) were synthesized. The biological evaluation of these compounds (5 and 6, respectively) showed a general increase of cytotoxicity, as observed in first-generation anticancer taxanes.
Keywords :
Methoxylated , Newer generation taxoids , Paclitaxel , IDN5109 , IDN5390
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
