Title of article :
A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents
Author/Authors :
Anu Agarwal، نويسنده , , Kumkum Srivastava، نويسنده , , S.K. Puri، نويسنده , , S. Sinha، نويسنده , , Prem M.S. Chauhan، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A small library of 20 trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial and antitubercular activities. Out of the total screened compounds, 16 compounds have shown in vitro antimalarial activity against Plasmodium falciparum in the range of 0.25–2 μg/mL and 8 compounds have shown antitubercular activity against Mycobacterium tuberculosis H37Ra, at a concentration of 12.5 μg/mL.
Keywords :
combinatorial chemistry , malaria , solid phase synthesis , Dihydrofolate reductase
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
