Author/Authors :
Joseph Pontillo، نويسنده , , Joe A. Tran، نويسنده , , Nicole S. White، نويسنده , , Melissa Arellano، نويسنده , , Beth A. Fleck، نويسنده , , Dragan Marinkovic، نويسنده , , Fabio C. Tucci، نويسنده , , John Saunders، نويسنده , , Alan C. Foster، نويسنده , , Chen Chen، نويسنده ,
Abstract :
Synthesis and structure–activity relationship studies of a series of cyclohexylpiperazines bearing an amide side chain as ligands of the MC4 receptor are discussed. Compounds such as 11i from this series are potent agonists (EC50 = 33 nM, IA = 96%).
Keywords :
receptor , Melanocortin-4 , agonist , synthesis , Cyclohexylpiperazine
