Title of article :
N-[(3S)-1-Benzylpyrrolidin-3-yl]-(2-thienyl)benzamides: Human dopamine D4 ligands with high affinity for the 5-HT2A receptor
Author/Authors :
Jalaj Arora، نويسنده , , Michel Bordeleau، نويسنده , , Laurence Dube، نويسنده , , Keith Jarvie، نويسنده , , Lucy Mazzocco، نويسنده , , Jack Peragine، نويسنده , , Ashok Tehim، نويسنده , , Ian Egle، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Pages :
4
From page :
5253
To page :
5256
Abstract :
A series of N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides 8 has been prepared and found to bind with high affinity to the human D4 (hD4) and 5-HT2A receptors. Several compounds displayed selectivity for these receptors versus hD2 and α1 adrenergic receptors of over 500-fold.
Keywords :
Serotonin , D4 , Schizophrenia , 5-HT2A , Dopamine
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2005
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
796167
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=796167
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