Title of article
Inhibition of Tpl2 kinase and TNF-α production with 1,7-naphthyridine-3-carbonitriles: Synthesis and structure–activity relationships
Author/Authors
Lori Krim Gavrin، نويسنده , , Neal Green، نويسنده , , Yonghan Hu، نويسنده , , Kristin Janz، نويسنده , , Neelu Kaila، نويسنده , , Huan-Qiu Li، نويسنده , , Steve Y. Tam، نويسنده , , Jennifer R. Thomason، نويسنده , , Ariamala Gopalsamy، نويسنده , , Greg Ciszewski، نويسنده , , John W. Cuozzo، نويسنده , , J. Perry Hall، نويسنده , , Sang Hsu، نويسنده , , Jean-Baptiste Telliez، نويسنده , , Lih-Ling Lin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
5288
To page
5292
Abstract
The synthesis and structure–activity studies of a series of 6-substituted-4-anilino-[1,7]-naphthyridine-3-carbonitriles as inhibitors of Tpl2 kinase are described. The early exploratory work described here may lead to the discovery of compounds with significant therapeutic potential for treating rheumatoid arthritis and other inflammatory diseases.
Keywords
Tpl2 kinase , 1 , 7-Naphthyridine-3-carbonitriles
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796175
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