Author/Authors :
Pui-Kai Li، نويسنده , , Zili Xiao، نويسنده , , Zhigen Hu، نويسنده , , Bulbul Pandit، نويسنده , , Yanjun Sun، نويسنده , , Dan L. Sackett، نويسنده , , Karl Werbovetz، نويسنده , , James Andrew Lewis، نويسنده , , Jayasekar Johnsamuel، نويسنده ,
Abstract :
A series of compounds originally derived from the vascular endothelial growth factor receptor tyrosine kinase inhibitor, SU5416, was synthesized and evaluated. The most potent compound in this series, compound 7, structurally resembles the potent anti-microtubule agent Combretastatin A-4, inhibited tubulin polymerization, and showed potent growth inhibitory activities on both prostate and breast cancer lines with IC50 values in low to subnanomolar range.
