Title of article
Conformationally restricted analogs of Combretastatin A-4 derived from SU5416
Author/Authors
Pui-Kai Li، نويسنده , , Zili Xiao، نويسنده , , Zhigen Hu، نويسنده , , Bulbul Pandit، نويسنده , , Yanjun Sun، نويسنده , , Dan L. Sackett، نويسنده , , Karl Werbovetz، نويسنده , , James Andrew Lewis، نويسنده , , Jayasekar Johnsamuel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
5382
To page
5385
Abstract
A series of compounds originally derived from the vascular endothelial growth factor receptor tyrosine kinase inhibitor, SU5416, was synthesized and evaluated. The most potent compound in this series, compound 7, structurally resembles the potent anti-microtubule agent Combretastatin A-4, inhibited tubulin polymerization, and showed potent growth inhibitory activities on both prostate and breast cancer lines with IC50 values in low to subnanomolar range.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796192
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