Author/Authors :
Ashis K. Saha، نويسنده , , Li Liu، نويسنده , , Richard Simoneaux، نويسنده , , Bart DeCorte، نويسنده , , Christophe Meyer، نويسنده , , Stacy Skrzat، نويسنده , , Henry J. Breslin، نويسنده , , Michael J. Kukla، نويسنده , , Dave W. End، نويسنده ,
Abstract :
A novel series of potent inhibitors of Ras farnesyl transferase possessing a 1,2,4-triazole pharmacophore is described. These inhibitors were discovered from a parallel synthesis effort and were subsequently optimized to in vitro IC50 value of less than 1 nM.
Keywords :
parallel synthesis , ras , Farnesyl transferase , triazole
