Title of article
Targeting the DNA minor groove with fused ring dicationic compounds: Comparison of in silico screening and a high-resolution crystal structure
Author/Authors
Nancy H. Campbell، نويسنده , , David A. Evans، نويسنده , , Michael P.H. Lee، نويسنده , , Gary N. Parkinson، نويسنده , , Stephen Neidle، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
15
To page
19
Abstract
The crystal structure of the DNA minor groove biphenyl benzimidazole diamidine ligand DB819 has been determined, bound to the DNA sequence d(CGCGAATTCGCG)2, at a resolution of 1.36 Å. Conditions for reliable in silico docking that reproduce the observed position of the ligand in the minor groove have been determined.
Keywords
DNA minor groove , crystallography , In silico screening , oligonucleotide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796303
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