Author/Authors :
Zheng Yin، نويسنده , , Sejal J. Patel، نويسنده , , Wei-Ling Wang، نويسنده , , Gang Wang، نويسنده , , Wai-Ling Chan، نويسنده , , K.R. Ranga Rao، نويسنده , , Jenefer Alam، نويسنده , , Duraiswamy A. Jeyaraj، نويسنده , , Xinyi Ngew، نويسنده , , Viral Patel، نويسنده , , David Beer، نويسنده , , Siew Pheng Lim، نويسنده , , Subhash G. Vasudevan and David L. Ollis، نويسنده , , Thomas H. Keller، نويسنده ,
Abstract :
Substrate-based tetrapeptide inhibitors with various warheads were designed, synthesized, and evaluated against the Dengue virus NS3 protease. Effective inhibition was achieved by peptide inhibitors with electrophilic warheads such as aldehyde, trifluoromethyl ketone, and boronic acid. A boronic acid has the highest affinity, exhibiting a Ki of 43 nM.
