Title of article
Peptide inhibitors of dengue virus NS3 protease. Part 1: Warhead
Author/Authors
Zheng Yin، نويسنده , , Sejal J. Patel، نويسنده , , Wei-Ling Wang، نويسنده , , Gang Wang، نويسنده , , Wai-Ling Chan، نويسنده , , K.R. Ranga Rao، نويسنده , , Jenefer Alam، نويسنده , , Duraiswamy A. Jeyaraj، نويسنده , , Xinyi Ngew، نويسنده , , Viral Patel، نويسنده , , David Beer، نويسنده , , Siew Pheng Lim، نويسنده , , Subhash G. Vasudevan and David L. Ollis، نويسنده , , Thomas H. Keller، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
36
To page
39
Abstract
Substrate-based tetrapeptide inhibitors with various warheads were designed, synthesized, and evaluated against the Dengue virus NS3 protease. Effective inhibition was achieved by peptide inhibitors with electrophilic warheads such as aldehyde, trifluoromethyl ketone, and boronic acid. A boronic acid has the highest affinity, exhibiting a Ki of 43 nM.
Keywords
Peptide inhibitors , Dengue virus NS3 protease
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796307
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