Title of article :
Synthesis of the PPARβ/δ-selective agonist GW501516 and C4-thiazole-substituted analogs
Author/Authors :
Raquel Pereira، نويسنده , , Claudine Gaudon، نويسنده , , Beatriz Iglesias، نويسنده , , Pierre Germain، نويسنده , , Hinrich Gronemeyer، نويسنده , , Angel R. de Lera، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
6
From page :
49
To page :
54
Abstract :
Sequential, position-selective, Pd-catalyzed cross-coupling reactions of 2,4-dibromo-5-hydroxymethylthiazole provided the scaffold for the synthesis of GW501516, the most potent PPARβ/δ agonist yet described, and equally selective analogs at the thiazole-C4 position.
Keywords :
PPAR , thiazoles , Stille reactions , Suzuki reactions , Nuclear receptors
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2006
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
796310
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=796310
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