Title of article
Pyrazole CCK1 receptor antagonists. Part 2: SAR studies by solid-phase library synthesis and determination of Free–Wilson additivity
Author/Authors
Clark Sehon، نويسنده , , Kelly McClure، نويسنده , , Michael Hack، نويسنده , , Magda Morton، نويسنده , , Laurent Gomez، نويسنده , , Lina Li، نويسنده , , Terrance D. Barrett، نويسنده , , Nigel Shankley، نويسنده , , J. Guy Breitenbucher، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
77
To page
80
Abstract
High-throughput screening revealed compound 1 as a potent antagonist of the CCK1 receptor. Here, we disclose the synthesis of combinatorial libraries by solid-phase synthesis on Kenner ‘safety catch’ resin. Additive QSAR models were used to determine a lack of consistent additive SAR within the matrix.
Keywords
combinatorial , Additivity , cholecystokinin , QSAR , CCK1
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796316
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