Title of article :
Photoreactive threading agent that specifically binds to abasic sites in DNA
Author/Authors :
Alain Martelli، نويسنده , , Muriel Jourdan، نويسنده , , Jean-François Constant، نويسنده , , Martine Demeunynck، نويسنده , , Pascal Dumy، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
We report the synthesis and study of a photoreactive nitrobenzamide containing acridine that specifically interacts at abasic site in DNA by threading intercalation and introduces under irradiation a lesion on the opposite strand at the unpaired pyrimidine.
Keywords :
DNA binders , DNA photodamaging , NMR , Abasic site , Acridine
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
