Title of article :
Synthesis and preliminary biological evaluation of (2S,1′R,2′S)- and (2S,1′S,2′R)-2-(2′-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues
Author/Authors :
Laura Amori، نويسنده , , Michaela Serpi، نويسنده , , Maura Marinozzi، نويسنده , , Gabriele Costantino، نويسنده , , Monica Gavilan Diaz، نويسنده , , Mette Brunsgaard Hermit، نويسنده , , Christian Thomsen، نويسنده , , Roberto Pellicciari، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Two novel constrained l-AP4 analogues, (2S,1′R,2′S)- and (2S,1′S,2′R)-2-(2′-phosphonocyclopropyl)glycines (7) and (8), were synthesized and evaluated as mGluR ligands. Compound 7 showed to be a group III mGluRs agonist with micromolar activity.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
