Title of article
Synthesis and preliminary biological evaluation of (2S,1′R,2′S)- and (2S,1′S,2′R)-2-(2′-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues
Author/Authors
Laura Amori، نويسنده , , Michaela Serpi، نويسنده , , Maura Marinozzi، نويسنده , , Gabriele Costantino، نويسنده , , Monica Gavilan Diaz، نويسنده , , Mette Brunsgaard Hermit، نويسنده , , Christian Thomsen، نويسنده , , Roberto Pellicciari، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
196
To page
199
Abstract
Two novel constrained l-AP4 analogues, (2S,1′R,2′S)- and (2S,1′S,2′R)-2-(2′-phosphonocyclopropyl)glycines (7) and (8), were synthesized and evaluated as mGluR ligands. Compound 7 showed to be a group III mGluRs agonist with micromolar activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796343
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