Author/Authors :
Ashok V. Purandare، نويسنده , , Honghe Wan، نويسنده , , Aiming Gao، نويسنده , , John Somerville، نويسنده , , Christine Burke، نويسنده , , Wayne Vaccaro، نويسنده , , Xiaoxia Yang، نويسنده , , Kim W. McIntyre، نويسنده , , Michael A. Poss، نويسنده ,
Abstract :
The design, synthesis, and activity of novel and selective small molecule antagonists of the CC chemokine receptor-4 (CCR4) are presented. Compound 8c was efficacious in a murine allergic inflammation model (ED50 30 mg/kg).
Keywords :
Chemokine receptor CCR4 , Antagonist , mDC , In vivo active , asthma
