Title of article
Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 1: Weakly basic azoles
Author/Authors
Richard C.A. Isaacs، نويسنده , , Mark G. Solinsky، نويسنده , , Kellie J. Cutrona، نويسنده , , Christina L. Newton، نويسنده , , Adel M. Naylor-Olsen، نويسنده , , Julie A. Krueger، نويسنده , , S. Dale Lewis، نويسنده , , Bobby J. Lucas Jr.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
338
To page
342
Abstract
Despite their relatively weak basicity, simple azoles, specifically imidazoles and aminothiazoles, can function as potent surrogates for the more basic amines (e.g., alkyl amines, amidines, guanidines, etc.) which are most often employed as the P1 ligand in the design of noncovalent small molecule inhibitors of thrombin.
Keywords
Anticoagulant , thrombin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796371
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